H2N2V1, Main, Exploration, bibRecord, 001D03

Prolonged Shedding of Amantadine-Resistant Influenza A Viruses by Immunodeficient Patients: Detection by Polymerase Chain Reaction-Restriction Analysis

Identifieur interne : 001D03 ( Main/Exploration ); précédent : 001D02; suivant : 001D04

Prolonged Shedding of Amantadine-Resistant Influenza A Viruses by Immunodeficient Patients: Detection by Polymerase Chain Reaction-Restriction Analysis

Auteurs : Alexander I. Klimov ; Elisabet Rocha ; Frederick G. Hayden ; Peter A. Shult ; L. Floretta Roumillat ; Nancy J. Cox [États-Unis]

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1995.

RBID : ISTEX:09FB087175A6CDF6B07F5036C72B97CE0F9E534C

Abstract

Consecutive A (H3N2) influenza virus isolates from 2 influenza virus-infected immunodeficient patients treated with amantadine were examined using a novel polymerase chain reaction (PCR)restriction analysis for resistance to this antiviral compound. The data indicate that immunodeficient patients may shed resistant viruses for prolonged periods and with different drug resistance mutations present at different times. This PCR-restriction technique allows rapid detection of amantadine- or rimantadine-resistant strains.

Url:

https://api.istex.fr/ark:/67375/HXZ-5F971RKZ-2/fulltext.pdf

DOI: 10.1093/infdis/172.5.1352

Affiliations:

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Le document en format XML

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<author><name sortKey="Roumillat, L Floretta" sort="Roumillat, L Floretta" uniqKey="Roumillat L" first="L. Floretta" last="Roumillat">L. Floretta Roumillat</name>
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<wicri:cityArea>Reprints or correspondence: Dr. Nancy J. Cox, Influenza Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta</wicri:cityArea>
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<front><div type="abstract">Consecutive A (H3N2) influenza virus isolates from 2 influenza virus-infected immunodeficient patients treated with amantadine were examined using a novel polymerase chain reaction (PCR)restriction analysis for resistance to this antiviral compound. The data indicate that immunodeficient patients may shed resistant viruses for prolonged periods and with different drug resistance mutations present at different times. This PCR-restriction technique allows rapid detection of amantadine- or rimantadine-resistant strains.</div>
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Prolonged Shedding of Amantadine-Resistant Influenza A Viruses by Immunodeficient Patients: Detection by Polymerase Chain Reaction-Restriction Analysis

Prolonged Shedding of Amantadine-Resistant Influenza A Viruses by Immunodeficient Patients: Detection by Polymerase Chain Reaction-Restriction Analysis

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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